Prof. Warwick Giles MB. BS(NSW), FRACOG, Ph.D(Syd). DDU. CMFM
Obstetrics & Gynaecology, Northern Clinical School
E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia
+61 (0 2) 9926 53192
+61 (0 2) 9926 6155
Biography
During the past 18 years my research interest has concentrated on maternal fetal medicine. Initially I was working in the team of Professor Brian Trudinger at Westmead Hospital in Sydney. My work on placental blood flow and umbilical artery Doppler ultrasound flow velocity waveforms formed the basis of my PhD studies and was continued during my time at Westmead. My work including a major interest in Doppler studies in multiple pregnancies has been presented at many national and international scientific meetings (the Perinatal Society of Australia and New Zealand, the Royal Australian College of Obstetricians and Gynaecologists, the Federation of Asia-Oceania Perinatal Societies, the Australian College of Paediatrics, the International Perinatal Doppler Society, the World Federation of Ultrasound in Medicine and Biology, the Australasian Society of Ultrasound in Medicine, the World Congress of Ultrasound In Obstetrics & Gynaecology, the European Perinatal Society, the World Placenta Associations, the Society of Perinatal Obstetricians [USA], Soceity for Maternal fetal medicine [USA] and the Society of Obstetric Medicine [USA]) and resulted in publications in refereed journals and several book chapters. I have also been an invited speaker at meetings in Australia, Indonesia, Malaysia, Singapore, Hong Kong , South Korea and the United States of America (University of Utah Medical School and the University of Colorado Health Sciences Centre).
Following my move to Newcastle where I was Chairperson of the Division of Obstetrics
and Gynaecology at John Hunter Hospital I have continued my interests in Doppler
ultrasound research. However my interests have expanded to include the assessment
of pre-term labour and its treatment. The Randomised Nitric Oxide Tocolysis
Trial (RNOTT), funded by the NHMRC, which was a multicentre randomised controlled
trial coordinated from Newcastle and includes the Mater Hospital (Brisbane),
the KK Hospital (Singapore), University of Singapore Hospital and the Prince
of Wales Hospital (Hong Kong) is now completed. As well as my research interests
I am active in the subspecialty of maternal fetal medicine in New South Wales
and am an executive member of the NSW Health Department Perinatal Services Network
(PSN), ex-chairperson of the PSN High Risk Obstetric Group and Chairperson of
the NSW Health Department Subcommittee on Prenatal Diagnoses for the Genetic
Services Advisory Committee. Most recently I moved to the Royal North Shore
Hospital and the University of Sydney.
Selected Publications
PUBLICATIONS
1 Diplylidiasis in a 57 year old woman. Bowen
T, Ladesen D, Giles W B, Crosier W, Anderson S E J. Medical Journal of
Australia (1977) 2:740
2 Fetal umbilical artery velocity waveforms. Giles W B, Trudinger B J, Cook C M. Journal of Ultrasound in Medicine (1982) 1(7) (suppl):98
3 Fetal umbilical artery velocity waveforms.
Giles W B, Trudinger B J, Cook C M.
Proceedings Tenth World
Congress of Obstetrics and Gynaecology, San Francisco, USA, October (1982):496
4 Placental vessel counting as an index of
placental flow resistance. Giles W B, Trudinger B J, Baird P
Journal of the Australian
Perinatal Society Proceedings of the Inaugural Congress (1983):60
5 Fetal umbilical artery flow velocity waveforms
and placental resistance. Trudinger B J, Giles W B, Cook C M.
Journal of the Australian
Perinatal Society Proceedings of the Inaugural Congress (1983):80
6 Feto placental blood-flow resistance and
placental microvascular anatomy: A Doppler ultrasound pathological correlation.
Trudinger B J, Giles W B, Cook C M.
Journal of Ultrasound
in Medicine (1983) 2(10) (Suppl):59
7 Uterine artery flow velocity waveforms in pregnancy. Trudinger B J, Giles W B, Cook C M. Journal of Ultrasound in Medicine (1983) 2(10) (Suppl):104
8 Fetal umbilical artery flow velocity waveforms
and placental resistance: Clinical significance. Trudinger B J, Giles W
B, Cook C M, Bombardieri J, Collins L.
British Journal of Obstetrics
and Gynaecology 1985.92:93-30
9 Fetal umbilical artery flow velocity waveforms
and placental resistance: Pathological correlation. Giles W B, Trudinger
B J, Baird P.
British Journal of Obstetrics
and Gynaecology 1985.92:31-38
10 Uteroplacental blood flow velocity-time
waveforms in normal and complicated pregnancies.Trudinger B J, Giles W
B, Cook C M, Jones L.
British Journal of Obstetrics
and Gynaecology 1985.93:171-175
11 A comparison of fetal heart rate monitoring
and umbilical artery waveforms in the recognition of fetal compromise.Trudinger
B J, Giles W B, Cook C M, Jones L.
British Journal of Obstetrics
and Gynaecology 1985.93:171-175
12 Fetal umbilical artery velocity flow waveforms
in twin pregnancies. Giles W B, Trudinger B J, Cook C M.
British Journal of Obstetrics
and Gynaecology 1985.92:490-497
13 Flow velocity waveforms in the maternal
uteroplacental and fetal umbilical placental circulations.Trudinger B J,
Giles W B, Cook C M.
American Journal of Obstetrics
and Gynecology 1985.152:155-163
14 Umbilical cord whole blood viscosity and
the umbilical artery flow velocity time waveforms: A comparison. Giles
W B, Trudinger B J, Palmer A.
British Journal of Obstetrics
and Gynaecology 1985.93:466-470
15 A comparison of fetal volume blood flow
measurement and umbilical artery velocity waveforms. Giles W B, Lingman
G, Marsal K, Trudinger B J.
Ultrasound in Medicine
and Biology. Supplement 1. 1985,238.
16 Fetal circulatory changes in imminent intrauterine
asphyxia. Marsal K, Lingman G, Laurin J, Giles W B.
Ultrasound in Medicine
and Biology. Supplement 1. 1985,241.
17 Fetal volume blood flow and umbilical artery
flow velocity waveform analysis: A comparison. Giles W B, Lingman G, Marsal
K, Trudinger B J.
British Journal of Obstetrics
and Gynaecology 1986. 93:461-465
18 Epidural anaesthesia for Caesarean section
and its effect on maternal uterine and foetal umbilical placental arterial
blood flow velocity-time waveforms.
Lah F, Giles W B, Trudinger
B J. Canadian Anaesthetists' Society Journal 1985. 32:S76
19 Flow velocity waveforms in the maternal
utero-placental and fetal umbilical circulations. Trudinger B J, Giles
W B, Cook C M.
Journal of the Australian
Perinatal Society. Proceedings of the Second Congress. 1985,125
20 A comparison of fetal volume blood flow
measurement and umbilical artery velocity waveforms. Giles W B, Trudinger
B J, Lingman G, Marsal K.
Journal of the Australian
Perinatal Society. Proceedings of the Second Congress. 1985,129
21 Umbilical artery flow velocity waveforms
in twin pregnancy. Giles W B, Trudinger B J, Cook C M.
Journal of the Australian
Perinatal Society. Proceedings of the Second Congress. 1985,129
22 Umbilical waveforms in twin pregnancy. Giles W B, Trudinger B J, Cook C M. Acta Geneticae Medicae et Gemellologiae/Twin Research 1985, 34:3-4
23 Umbilical artery flow velocity waveforms:
altering resistance by embolisation. Trudinger B J, Connelly A, Stevens
D, Giles W B, Hales J R S, Alexander G.
Proceedings Society for
Gynaecological Investigation. 33rd Annual Meeting.Abstract No. 24.1986.
24 Evaluation of the carotid, aortic and umbilical
blood velocity waveforms in the human fetus. Lingman G, Marsal K, Giles
W B.
11th Annual Conference
Society of Fetal Physiology. Oxford. Abstract No C33. 1984
25 The effect of epidural anaesthesia for
Caesarean section on maternal and fetal umbilical blood flow.Giles W B,
Lah F X, Trudinger B J.
British Journal of Obstetrics
and Gynaecology 1986, 94:55-59
26 Epidural anaesthesia and its effect on
maternal uterine and fetal umbilical placental arterial waveforms. Giles
W B, Lah F X, Trudinger B J.
Journal of the Australian
Perinatal Society, Proceedings of the Third Congress, 1985, 116.
27 Doppler ultrasound features of stenosis
of the aorta in a pregnancy complicated by Takayasu's aortitis.
Giles W B, Young A A,
Howlin K J, Cook C M, Trudinger B J. British Journal of Obstetrics and
Gynaecology 1986, 94:907-909
28 Umbilical artery velocity waveforms a randomised
trial controlled trial. Trudinger B J, Cook C M, Giles W B, Connelly A,
Thompson R S.
Lancet 1987 i:188-190
29 Doppler ultrasound and blood flow in obstetrics.
Trudinger B J, Thompson R S, Giles W B.
In: Ultrasound Annual
1986. Eds Sanders R C and Hill M C.Raven Press. New York.pp 39-67
30 Umbilical artery velocity waveforms: Normal
reference values for AB ratio and Pourcelot ratio. Thompson R S, Trudinger
B J, Cook C M, Giles W B.
British Journal of Obstetrics
and Gynaecology 1988, 95: 589-595
31 Doppler assessment in multiple pregnancy.
Giles W B.
In: Seminars in Perinatology
1987. Eds Creasy R K and Warshaw J B, Grune and Stratton Volume 11:369-374.
32 Umbilical artery flow velocity waveforms
in twin pregnancy outcome. Giles W B, Trudinger B J, Cook C M, Connelly
A.
Obstetrics and Gynecology
1988, 72:894-897
33 Low dose aspirin therapy improves fetal
weight in umbilical placental insufficiency. Trudinger B J, Cook C M, Thompson
R S, Giles W B, Connelly A.
American Journal of Obstetrics
and Gynecology 1988, 159:681-685
34 Umbilical artery flow velocity waveform
analysis in normal ovine pregnancy and after carunculectomy.Giles W B,
Trudinger B J, Stevens D, Alexander G, Bradley L.
Journal of Developmental
Physiology 1988, 11:135-138
35 Teenage pregnancy in Western Sydney Bradford
J, Giles W B
Australian and New Zealand
Journal of Obstetrics and Gynaecology 1989, 29:1-4
36 The effects of prostacyclin and thromboxane
analogue (U46619) on the fetal circulation and umbilical flow velocity
waveforms.
Trudinger B J, Connelly
A, Giles W B, Hales J R S, Wilcox G R. Journal of Developmental Physiology
1989, 11:179-184
37 Outpatient methadone program for pregnancy
heroin using women. Giles W B, Patterson T , Sanders F, Batey R, Thomas
D, Collins J.
Australian & New Zealand
Journal of Obstetrics and Gynaecology 1989, 29:225-229
38 Clinical and pathological correlations
of umbilical artery waveforms: The meaning of the waveform indices of resistance.
Trudinger B J, Giles W B.
In: Doppler Blood Flow
Studies. Clinics in Obstetrics and Gynecology. 1988, 32(4):669-678.
39 Low dose aspirin improves fetal weight
in umbilical placental insufficiency. Trudinger B J, Cook C M, Thompson
R S, Giles W, Connelly A.
Lancet July 23, 1988
40 Ureteric endometriosis: 3 case reports
and a review of the literature. Bradford J, Ireland E, Giles W B.
Australian & New Zealand
Journal of Obstetrics and Gynaecology 1989, 29:421-425
41 Trauma during pregnancy - A review. Bowman
M, Giles W B, Deane S.
Australian & New Zealand
Journal of Obstetrics and Gynaecology 1989, 29:389-394
42 Letter. Journal of Ultrasound in Medicine. 1989, 8:531
43 Umbilical artery waveforms in triplet pregnancy. Giles W B, Trudinger B J, Cook C M, Connelly A. Obstetrics and Gynecology 1990, 75:813-816
44 Low-dose aspirin and twin pregnancy. Trudinger B J, Cook C M, Giles W B, Connelly A J, Thompson R S. Lancet, November 18, 1989, 1214
45 Managing HIV + pregnancies. Giles W. In:
Children and adolescents with HIV/AIDS: An update.
Proceedings of Symposium
in Caring for Children and Adolescents with HIV/AIDS. University of NSW.
November 1989. Eds. Waters B, Ziegler J, Gray A.
46 Methadone levels and neonatal withdrawal. Mack G, Thomas D, Giles W, Buchanan N. Journal of Paediatrics and Childhealth. 1991, 27:96-100
47 Down Syndrome and MSAFP. Jacobs S, Giles W. Australian & New Zealand Journal of Obstetrics and Gynaecology 1990, 30:335-340
48 Fetal umbilical artery velocity waveforms
and subsequent neonatal outcome. Trudinger B J, Cook C M, Giles W B, Ng
S, Fong E, Connelly A J, Wilcox W.
British Journal of Obstetrics
and Gynaecology 1991, 98:378-384
49 Discrepancies in Haemoglobin Levels. Giles W B, Trudinger B J. American Journal of Obstetrics and Gynecology 1990, 163:1713
50 Doppler umbilical artery studies in the
twin-twin transfusion syndrome. Giles W B, Trudinger B J, Cook C M, Connelly
A J.
Obstetrics and Gynecology
1990, 76:1097-1099
51 The short-term outcome of singleton infants
delivered before 28 weeks. Nicholl M C, Giles W B.
Australian & New Zealand
Journal of Obstetrics and Gynaecology 1991, 31:103-107
52 The short-term outcome of infants of multiple
pregnancies delivered before 28 weeks gestation. Nicholl M C, Giles W B.
Australian & New Zealand
Journal of Obstetrics and Gynaecology 1991, 31:108-110
53 The biophysical assessment of placental and membrane dysfunction. Giles W B. Reproduction, Fertility & Development 1991, 3:483-488
54 Placental microvascular changes in twin
pregnancies with abnormal umbilical artery waveforms. Giles W B, Trudinger
B J, Cook C-M, Connelly A J.
Journal of Maternal-Fetal
Investigation 1991, 1:103 (abstract).
55 Necrotising enterocolitis in a perinatal centre. Lui K. Nair A, Giles W, Morris J, John E. Journal of Paediatrics and Child Health 1992, 28:47-49.
56 Antenatal care of low risk obstetric patients
by midwives - a randomised controlled trial. Giles W, Collins J, Ong F,
MacDonald R.
Medical Journal of Australia
1992, 157:158-161.
57 Review of obstetric operative intervention rates. Foote A, Giles W. Asia-Oceania Journal of Obstetrics & Gynaecology 1992, 18:195-198.
58 Reduction in human fetal umbilical-placental vascular resistance by glyceryl trinitrate. Giles W, O'Callaghan S, Boura A, Walters W. Lancet 1992, 340:856.
59 Could it be HIV? Obstetrics and Gynaecology Practice. Giles W, Clezy K. Medical Journal of Australia 1992, 158:263.
60 Antenatal care of low risk patients by midwives (letter). Giles W. Medical Journal of Australia 1992,157:575.
61 Birth asphyxia and cerebral palsy. Giles W. RACOG Continuing Education Resource Manual. Resource Unit 90, 1992, 90.1-7. RACOG, 1992, Melbourne
62 Placental microvascular changes in twin
pregnancies with abnormal umbilical artery waveforms. Giles WB, Trudinger
BJ, Cook CM, Connelly AJ.
Obstetrics and Gynecology
1993;81:556-559.
63 Clinical use of Doppler ultrasound in pregnancy: Information from six randomised trials. Giles W, Bisits A. Fetal Diagnosis and Therapy 1993;8:247-255.
64 HIV infection in Obstetric and Gynaecological
practice. Giles WB, Clezy K. Ed. Stewart G. In: Could it be HIV.
Australasian Medical Publishing
Company. pp 60. Kingsgrove. 1993.
65 Diabetes in pregnancy. Coulthard A, Giles
WB. In: Shared Obstetric Care. A Resource Manual,For the 5th Course
in Shared Obstetric Care.
Eds Brinsmead M, Raffan
B, Sales M. pp 55-58. The Hunter Postgraduate Medical Institute, The University
of Newcastle. 1993
66. Tests of Fetal health. Giles WB. In: Shared
Obstetric Care. A Resource Manual, For the 5th Course in Shared Obstetric
Care.
Eds Brinsmead M, Raffan
B, Sales M. pp 115-120. The Hunter Postgraduate Medical Institute, The
University of Newcastle. 1993
67. HIV and Women. In: The AIDS Manual.
Third Edition. Eds: Gold G, Penny R, Ross M, Morey S, Stewart G, Donovan
B and Berenger S.
MacLennon and Petty, Sydney,
1994, pp105-112.
68. Vascular responses to sodium nitropruside
in the human fetal-placental circulation.Read MA, Giles WB, Leitch IM,
Boura ALA, Walters WAW.
Reproduction, Fertility
and Development 1995;7:1557-1561
69. Australian collaborative trial of antenatal
thyrotropin releasing hormone (ACTOBAT) for the prevention of neonatal
respiratory disease.
The ACTOBAT Study Group.
Giles et al. Lancet 1995;345:877-882
70. Corticotropin-Releasing Hormone-Induced
vasodilatation in the human fetal-placental circulation: Involvement
of nitric oxide-cyclic guanosine
3',5'-monophosphate-mediated
pathway. Clifton VL, Read MA, Leitch IM, Giles W, Boura ALA, Robinson PJ,
Smith R.
Journal of Clinical and
Endocrinological Medicine 1995;80:2888-2893.
71. Ovine fetal blood flow responses to nitric
oxide deficiency and nitric oxide donor therapy.Giles W, Read M, Falconer
J, O’callaghan S.
American Journal of Obstetrics
and Gynecology 1996;174:488.
72. Umbilical cord blood levels of corticotropin
releasing hormone in pregnancies complicated by abnormal umbilical artery
Doppler waveforms.
Giles W, McLean M, Davies
J, Smith R. Obstetrics and Gynaecology 1996;87:107-111.
73. Reproductive Health Care for Women and Babies. Book Review for New England Journal of Medicine, March 28, 1996.
74. Prolonged induction to delivery time in
termination of pregnancy in fetuses having a neural tube defect or hydrocephalus
using 16,16 - dimethyl - PGE1 - methyl
ester (gemeprost). Nesbitt
D, Giles W. Australian New Zealand Journal of Obstetrics and Gynaecology
1996;36:300-303.
75. Nitric oxide synthase activity and placental
insufficiency. Giles WB, O?Callaghan SP, Read MA, Gude NM, King RG, Brennecke
SP.
Obstetrics and Gynecology
1997;89:49-52.
76. Ovine fetal umbilical artery Doppler systolic
diastolic ratios are raised and nitric oxide synthase. Giles W, Falconer
J, Read M, Leitch I.
Obstetrics and Gynecology
1997;89:53-56.
77. Elaboration of stem vessels in growth
restricted pregnancies with abnormal umbilical artery Doppler waveforms.
Trudinger BJ, Giles WB.
British Journal of Obstetrics
and Gynaecology 1996;103:487-488.
78. Examination of a low cost pocket Doppler for fetal assessment. Lockett ML, Bisits AM, Giles WB. Ultrasound in Obstetrics and Gynaecology 1998;11:44-47.
79. Large meningioma complicating pregnancy. Otton GR, Giles W, Walters WA. Australian New Zealand Journal of Obstetrics and Gynaecology 1997;37:466-9.
80. Australian Collaborative Trial of
Antenatal Thyrotropin-Releasing Hormone:Adverse effects at 12-month follow-up.
Crowther CA, Hiller JE,
Haslam RG, Robinson JS, ACTOBAT Study Group Giles W et al. Pediatrics 1997;99:311-317.
81. Realtime ultrasound diagnosis over a wide-area
network (WAN) using off-the-shelf components. Falconer J, Giles W, Villanueva
H.
Journal of Telemedicine
and Telecare 1997;3(1):28-30.
82. CRH - A biochemical predictor of preterm
delivery in a pilot randomised trial of the treatment of preterm labour.
Bisits A, Madsen G, McLean M, O'Callaghan S,
Smith R, Giles W. American
Journal of Obstetrics and Gynecology 1998;178:862-866.
83. Chapter 7. Doppler ultrasound in multiple pregnancies. Giles WB. In: Balliere’s Clinical Obsterics and Gynaecology 1998: 12(1);77-89 Eds Neilsen J.
84. Ovine fetal responses to maternal nitric
oxide treatment. W. Giles, M. Read, J. Falconer, S. O’Callaghan, B. Abernethy,
A. Bisits.
American Journal
of Obstetrics and Gynecology 1998;178:S43.
85. The effect of fetal fibronectin usage
on admissions to a tertiary maternal fetal medicine unit and cost savings.W.
Giles, M. Knox, G. Madsen, A. Bisits. R. Smith.
American Journal
of Obstetrics and Gynecology 1998;178:S121.
86. U46619 mediated vasoconstriction of the
fetal placental vasculature in vitro in normal and hypertensive pregnancies.
Read MA, Leitch
IM, Giles WB, Bisits A, Boura ALA, Walters WAW. Journal of Hypertension.
1999;17:389-96.
87. Antenatal hospitalisations in New South Wales 1995/96. Adelson PL, Child AG, Giles WB, Henderson-Smart DJ. Medical Journal of Australia 1999;170:211-15.
88. Matrix metalloprotienase-9 activity in
urine of patients at risk of premature delivery. Agrez MV, Gu X, Giles
WB. American Journal of Obstetrics and Gynecology
1999; 181:387-8.
89. The effect of fetal fibronectin testing
on admissions to a tertiary maternal fetal medicine unit and cost savings.
Giles W, Bisits A, Knox M, Madsen G, Smith R.
American Journal of Obstetrics
and Gynecology 2000:182:439-42.
90. Vascular Doppler techniques. Giles WB. Obstetrics and Gynecology Clinics of North America 1999;26:595-606.
91. Regulation of Parturition: The role of
CRH. Smith R, Chan E-C, Mesiano S, Cheng Y-H, Bowman M, Clifton V, Madsen
G, Fitter JT, Giles W, Bisits A.
Chapter 24, Hormones and
Women’s Health: The Reproductive Years. Gordon and Breach Science Publishers,
1999
92. The Doppler assessment in multiple pregnancy
study (DAMP) and metaanalysis of Doppler and twins. Giles W, Bisits A,
O’Callaghan S.
American Journal of Obstetrics
and Gynecology 2000;182:S17.
93. Fetal placental vascular responses to
corticotropin-releasing hormone in vitro. Effects of variation in
oxygen tension.
Donoghue JF, Leitch IM,
Boura ALA, Walters WAW, Giles WB, Smith R, Read MA. Placenta 2000;21:711-7.
94. Obstetric and perinatal outcomes from
the Australian and New Zealand Twin-Transfusion Syndrome Registry.
Dickinson JE, Evans SF,
and the Australian and New Zealand Twin-Transfusion Syndrome Registry.
American Journal of Obstetrics
and Gynecology 2000:182:706-12.
95. First trimester ultrasound with nuchal
translucency measurement for Down syndromeRisk estimation using software
developed by the Fetal Medicine Foundation,
United Kingdom – the first
2000 examinations in Newcastle, New South Wales, Australia. O’Callaghan
SP, Giles WB, Raymond SP, McDougall V, Morris K, Boyd J.
Australian and New Zealand
Journal of Obstetrics and Gynaecology 2000:40:292-295.
96. Successful vaginal delivery in a woman
with amyoplasia. Hackett A, Giles W, James S. Australian and New Zealand
Journal of Obstetrics and Gynaecology
2000;40:461-463.
97. Doppler ultrasound in twin pregnancy. Giles W. Fetal and Maternal Medicine Review 2001;12:93-103.
98. Metalloproteinases and cervical maturation.
Giles W, Agrez M. In: The Endocrinology of Parturition. Basic Sciences
and Clinical Application. Smith R (Ed).
Frontiers in Hormone Research.
Karger, Basel. 2001 (in press)
99. Alterations in placental vascular function
in asthmatic pregnancies. Clifton VL, Giles WB, Smith R, Bisits AT, Hempenstall
P, Lessell C, Gibson P.
American Journal of Respiratory
Medicine and Clinical Care Medicine 2001;164:546-553.
100. Maternal plasma corticotropin-releasing
hormone trajectories vary depending on the etiology of preterm delivery.
McGrath S, McLean M, Bisits
A, Giles W, Smith R. American Journal of Obstetrics and Gynecology 2001
(in press).
101. The randomised nitric oxide tocolysis
trial. Giles W, Knox M, Madsen G, Bisits A, Gill A, Smith R, Jones I, Kwek
K, Leung D.
American Journal of Obstetrics
and Gynecology 2001;184:S6.
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