Professor Roger Smith MB.BS (Syd) FRACP Ph.D (London)
Contact Details
 |
Professor
of Endocrinology
Faculty
of Medicine,
Postal Address.
|
Appointments
Director
Mother
and Babies Research Centre
Endocrinology
Unit, John Hunter Hospital
Memberships
Endocrine Society (USA)
Endocrine Society of Australia
Interests
All aspects of the endocrinology of pregnancy, especially the role and regulation of placental corticotrophing releasing hormone
Publications
l Smith R, Donald RA, Espiner EA, Stronach SC & Edwards IA. Normal adults
and subjects with hypogonadotrophic hypogonadism respond differently to D-Ser
(TBU)6-LH-RH-EA10.
Journal of Clinical Endocrinology and Metabolism, 48(1):167-170 1979.
2 Smith R, Donald RA, Espiner EA & Stronach S. The effects of prolonged
administration of D-Ser (TBU)6-LH-RH-EA10 (Hoe 766) in subjects with hypogonadotrophic
hypogonadism.
Clinical Endocrinology, 11(5):553-559 1979.
3 Smith R, Donald RA, Espiner EA, Glatthaar C, Abbott G & Scandrett M.
The effect of different treatment regimes on hormonal profiles in congenital
adrenal hyperplasia.
Journal of Clinical Endocrinology and Metabolism, 51(2):230-236 1980.
4 Glatthaar C, Smith R, Espiner EA, Donald RA & Hinton D. 1,25-Dihydroxy-vitamin D3: a new treatment for hypoparathyroidism. New Zealand Medical Journal, 669(92):267-271 1980.
5 Glatthaar C, Donald RA, Smith R & McRae CU. Pituitary function in normoprolactinaemic infertile men receiving bromocriptine. Clinical Endocrinology, 13(5):455-459 1980.
6 Moore MP, Smith R, Donald RA, Espiner EA & Stronach S. The effects of
different dose regimes of D-Ser (TBU)6-LH-RH-EA10 (HOE 766) in subjects with
hypogonadotrophic hypogonadism.
Clinical Endocrinology, 14:93-97 1981.
7 Gaillard RC, Grossman A, Smith R, Rees LH & Besser GM. The effects of
a met-enkephalin analogue on ACTH, beta-LPH, beta-endorphin and met-enkephalin
in patients with adrenocortical disease.
Clinical Endocrinology, 14:471-478 1981.
8 Smith R, Grossman A, Gaillard R, Clement-Jones V, Ratter S, Mallinson J, Lowry PJ, Besser GM & Rees LH. Studies on circulating met-enkephalin and ß-endorphin: normal subjects and patients with renal and adrenal disease. Clinical Endocrinology, 15:291-300 1981.
9 Smith R. Studies on circulating met-enkephalin and beta-endorphin in man. PhD. Thesis. University of London 1981.
10 Rees LH & Smith R. Recent Advances in Endocrinology and mineral metabolism Ed. O-Riordan 2:1-15 1982.
11 Grossman A, Smith R, Van Loon GR, Brown GM, Rees LH & Besser GM. Circulating
catecholamines, melatonin and enkephalin in man following administration of
a met-enkephalin analogue.
Neuroscience Letters, 4 1982.
12 Smith R & Rees LH. Endogenous Opiate Peptides in Current Concepts. Williams, E.D. Editor, Praeger Publishers on Behalf of the Royal College of Pathologists, 75-100 1982.
13 Clement-Jones V, Corder R, Smith R, Medbak S, Lowry PJ, Rees LH & Besser GM. Met?enkephalin and related peptides in man in "Regulatory Peptides: from Molecular Biology to Function" Raven Press, New York 379-386 1982.
14 Smith R. Development of Techniques to Determine the Role of Cerebrospinal Fluid Endorphins in Stress and Pain. 2nd Australian International Congress on Contemporary Acupuncture 1983.
15 Kiser SR, Jackson S, Smith R, Rees LH, Lowry PJ & Besser GM. Endorphin?related peptides in rat cerebrospinal fluid. Brain Research, 288:187-192 1983.
16 Smith R. Calcium Metabolism and Osteoporosis. Proc. Eighth Ann. Pharm. Course. Ed. Goodman. Publisher. Pharm. Soc. Aust., 223?229 1984.
l7 Smith R. Current Therapy of Thyroid Disease. Proc. Eighth Ann. Pharm. Course. Ed. Goodman. Publisher Pharm. Soc. Aust., 230-233 1984.
l8 Smith R. Hypothalamus and Pituitary-Recent Advances. Proc. Eighth Ann. Pharm. Course. Ed. Goodman. Publisher Pharm. Soc. Aust., 234-237 1984.
l9 Smith R. The Endocrinology of Infertility. Proc. Eighth Ann. Pharm. Course. Ed. Goodman. Publisher Pharm. Soc. Aust., 238-240 1984.
20 Smith R. Endorphins: The Body's Own Opiates - Possible Function. Proc. Eighth Ann. Pharm. Course. Ed. Goodman. Publisher. Pharm. Soc. Aust., 24l-243 1984.
2l Owens PC, Smith R, Green D & Falconer J. Effect of hypoglycemic stress on plasma and cerebrospinal fluid ß-endorphin in conscious sheep. Neuroscience Letters, 49:1-6 1984.
22 Falconer J, Owens PC & Smith R. Cannulation of the cisterna magna in sheep: a method for chronic studies of cerebrospinal fluid. Australian J.Exp. Biol. Med. Sci., 63(2):157-162 1985.
23 Brinsmead M, Smith R, Singh B, Lewin T & Owens P. Peripartum concentrations of beta-endorphin and cortisol and maternal mood states. Australian and New Zealand J. Obstetrics and Gynaecology, 25:194-197 1985.
24 Owens P, Lovelock M, Chan E-C, Falconer J, Ling N & Smith R. Secretion of N-terminal pro-opiomelanocortin-derived peptides in response to acute haemorrhagic stress in conscious sheep.Biochemical and Biophysical Research Communications, 133(2):648-653 1985.
25 Smith R, Grossman A, Gimson AES, Besser GM & Rees LH. Effect of liver and renal dysfunction on circulating methionine-enkephalin immunoreactivity. Neuroscience Letters, 60:301-305 1985.
26 Smith R, Besser GM & Rees LH. The effect of surgery on plasma ß-endorphin and methionine-enkephalin. Neuroscience Letters, 55:17-21 1985.
27 Smith R, Grossman A, Boyce MJ, Besser GM & Rees LH. Effect of histamine infusion on circulating methionine-enkephalin and catecholamine concentrations. Neuroscience Letters, 55:289-292 1985.
28 Smith R, Owens PC, Lovelock M, Chan E-C & Falconer J. Acute hemorrhagic stress in conscious sheep elevates immunoreactive ß-endorphin in plasma but not in cerebrospinal fluid. Endocrinology. 118(6):2572-2576 1986.
29 Smith R, Feletti G & Hughes J. Can Senior Students be Good Small-group Tutors? Herdsa News, 8(1):7-8 1986.
30 Smith R. The neuroendocrinology of the pregnant woman. Ed. Dennerstein Pub. Elsevier, 466-475 1986.
31 Singh B, Gilhotra M, Smith R, Brinsmead M, Lewin T & Hall C. Post-partum Psychoses and the Dexamethasone Suppression Test. Journal of Affective Disorders, 11:173-177 1986.
32 Smith R. Role of cerebrospinal fluid and plasma beta-endorphin in pain and stress. Medical Research 1985. Ed. NH&MRC. Publisher Federal Government Publishers l986.
33 Ross RJM, Borges F, Grossman A, Smith R, Ngahfoong L, Rees LH, Savage MO & Besser GM. Growth hormone pretreatment in man blocks the response to growth hormone-releasing hormone; evidence for a direct effect of growth hormone. Clinical Endocrinology, 26:117-123 1987.
34 Kusnecov AW, Husband AJ, King MG, Pang G & Smith R. In vivo effects of ß-endorphin on lymphocyte proliferation and Interleukin 2 production. Brain, Behaviour and Immunity, 1:88-97 1987.
35 Martyn P, Smith R, Owens PC, Lovelock M & Chan E-C. Immunoreactive ß-endorphin
and pro-g-melanotropin in the peripheral circulation
during the menstrual cycle.
Asia?Oceania Journal of Obstetrics and Gynaecology, 13(3):345-350 1987.
36 Smith R, Owens PC, Brinsmead MW, Singh B & Hall C. The nonsuppressibility of plasma cortisol persists after pregnancy. Hormone and Metabolic Research, 19:41-42 1987.
37 Owens PC & Smith R. Opioid peptides in blood plasma and cerebrospinal fluid during acute stress. In the Neuroendocrinology of Stress. Ed. Grossman, Pub. Bailliere's. Clinical Endocrinology and Metabolism International Practice and Research, 1(2):415-438 1987.
38 Owens PC, Smith R, Brinsmead MW, Hall C, Rowley M. Hurt D, Lovelock M, Chan E-C, Cubis J & Lewin T. Post-natal disappearance of the pregnancy-associated reduced sensitivity of plasma cortisol to feedback inhibition. Life Sciences, 41(14):1745-1750 1987.
39 Smith R. The placenta as a neuroendocrine organ. Neuroscience Letters, Supp 27, S24-S25, 1987.
40 Smith R. Relationship between mood disturbance and changes during pregnancy in the hypothalamic-pituitary adrenal axis. Psychosomatic Aspects of Reproductive Medicine and Family Planning. Ed G. D. Burrows, O. M. Petrucco, D. Llewellyn-Jones. AFFPA Inc., 69-72 1987.
41 Owens PC, Chan E-C, Lovelock M, Falconer J & Smith R. Immunoreactive methionine-enkephalin in cerebrospinal fluid and blood plasma during acute stress in conscious sheep. Endocrinology, 122(1):311-318 1988.
42 Chan E-C, Thomson M, Madsen G, Falconer J & Smith R. Differential processing
of corticotrophin-releasing hormone by the human placenta and hypothalamus.
Biochemical and Biophysical Research Communications, 153(3):1229-1235 1988.
43 Falconer J, Chan E-C, Madsen G, Thomson M, Davies J & Smith R. Secretion
of ß-endorphin into the maternal circulation by uteroplacental tissues
in response to hypoglycaemic stress.
Journal of Endocrinology, 118:R5-8 1988.
44 Thomson M, Chan E-C, Falconer J, Madsen G & Smith R. Secretion of corticotrophin-releasing hormone by superfused human placental fragments. Gynecol Endocrinol,, 2:87-100 1988.
45 Smith R, Lovelock M, Owens PC, Chan E-C & Falconer J. The effect of
repetitive haemorrhage on plasma cortisol, beta-endorphin and N-Terminal pro-opiomelanocortin
in conscious sheep.
Hormone and Metabolic Research, 20(10):612-615 1988.
46 Kusnecov AW, Husband AJ, King MG & Smith R. Modulation of mitogen-induced spleen cell proliferation and the antibody-forming cell response by beta-endorphin in vivo. Peptides 10:473-479 1988.
47 Thornton K, Lewin T, Cubis J, Brinsmead M, Smith R & Hurt D. Antepartum and postpartum depression: do any women suffer from both? In D. Llewellyn-Jones and S.Abraham (Eds), The Young, the Pregnant and the Elderly - Proceedings of the l6th Annual Congress of the Australian Society for Psychosomatic Aspects of Reproductive Medicine (A.S.P.A.R.M.) Melbourne: Ashwood House Medical. 97-104 1989.
48 Thomson M & Smith R. The action of hypothalamic and placental corticotropin-releasing factor on the corticotrope. Molecular and Cellular Endocrinology, 62:1-12 1989.
49 Owens PC, Owens JA, Lovelock M, Chan E-C, Falconer J, Robinson JS &
Smith R. Restriction of placental growth in sheep enhances placental metabolism
of fetal ß-endorphin-like immunoreactivity.
Journal of Developmental Physiology, 11:63-71 1989.
50 Levick MP, Lovelock M, Smith R & Saunders NA. Relation between plasma beta-endorphin and the ventilatory response to hypercapnia in humans. Clinical Science, 77(3):323-327 1989.
51 Smith R. Withdrawing Corticosteroids- How and When. Current Therapeutics, (Nov) 59-67 1989.
52 Smith R, Cubis J, Brinsmead M, Lewin T, Singh B, Owens P, Chan E-C, Hall
C, Adler M, Lovelock M, Hurt D, Rowley M & Nolan M. Mood changes, obstetric
experience and alterations in plasma cortisol, beta-endorphin and corticotrophin-releasing
hormone during pregnancy and the puerperium.
Journal of Psychosomatic Research, 34(1):53-69 1990.
53 Chan E-C, Thomson M, Madsen G, Boettcher B, Falconer J & Smith R. Large
molecular weight immunoreactive corticotrophin-releasing hormone has bioactivity
on superfused ovine pituitary cells. Journal of Neuroendocrinology, 2(1):95-101
1990.
54 Thomson M, Chan E-C, Falconer J, Madsen G, Geraghty S, Curryer N, Boulton
J & Smith R. Desensitization of superfused isolated ovine anterior pituitary
cells to human corticotropin-releasing factor. Journal of Neuroendocrinology,
2(2):181-187 1990.
55 Thomson M, Chan E-C, Davies J, Falconer J, Madsen G, Geraghty S & Smith
R. Intracellular mechanisms governing the acute phase of ß-endorphin secretion
from the corticotrope in vitro.
Neuroscience Letters, 110:343-348 1990.
56 Chan E-C, Brinsmead MW, Chen SE, Nanra R, Simm B, McLean M & Smith R.
Urinary corticotropin-releasing hormone immunoreactivity is elevated during
human pregnancy.
Gynecol. Endocrinol., 4:233-244 1990.
57 Madsen G, Chan E-C, Falconer J, Ho KY & Smith R. Reverse haemolytic plaque assay study of corticotrophin-releasing hormone and arginine vasopressin interaction in ovine corticotropes. Journal of Neuroendocrinology, 3(2):193-197 1991.
58 Smith R & Thomson M. Neuroendocrinology of the hypothalamic pituitary-adrenal axis in pregnancy and the peurperium. Bailliere's Clinical Endocrinology and Metabolism, 5(1):167-186 1991.
59 Davies JJ, Falconer J, Zhang H-P, Chan E-C, McLean M & Smith R. Perifused ovine placental tissue secretes ß-endorphin immunoreactivity. Journal of Reproduction, Fertility and Development, 3(4) 397-404 1991.
60 Falconer J, Davies JJ, Zhang H-P & Smith R. Release of IGF by the sheep
placenta in vitro.
Journal of Reproduction, Fertility and Development, 3(4) 379-384 1991.
61 Smith R, Chan E-C & Madsen G. The maternal hypothalamo-pituitary-adrenal axis in pregnancy and the puerperium. In Stress and Reproduction Ed Sheppard, Funder and Boublik, Raven Press. Serono Symposium 86:73-92 1991.
62 Livesey JH, Carne A, Clifford HG, Irvine HE, Ellis J. Evans MJ, Smith R & Donald RA. Structure of Equine Corticotropin-Releasing Factor. Peptides, 12:1437-1440 1991.
63 Smith R & Singh BS. "Hypothalamic-pituitary adrenal axis in postpartum psychosis" in The Picture Puzzle of Postpartum Psychiatric Illness Ed James A Hamilton Published by University of Pennsylvania Press. 1992.
64 Boulton TJC, Smith R & Single T. Psychosocial growth failure: a positive response to growth hormone and placebo. Acta Paeds Scandinavia, 81:322-325 1992.
65 Smith R & Chan E-C. The maternal stress response in pregnancy and the
puerperium.
Hormones in Gynecological Endocrinology. Parthenon Publishing, Editors Genazzani,A.R.
& Petraglia,F. Chapter 69:779-789 1992.
66 Chan E-C & Smith R. ß-Endorphin Immunoreactivity during Human
Pregnancy.
Journal of Clinical Endocrinology and Metabolism , 75(6):1453-1458 1992.
67 Gude NM, Boura AA, King RG, Brennecke SP, Jamal OS, Smith R & Walters WA. Evidence for attenuation by endothelium-derived relaxing factor of thormboxane A2 receptor-mediated vasoconstriction in the fetal vessels of perfused human placental lobules. Placenta, 13:597-605 1992.
68 McLean M, Walters WAW & Smith R. Prediction and early diagnosis of preterm labour - a critical review. Obstetrical & Gynecological Survey, 48:209-225 1993.
69 Chan E-C, Smith R, Lewin T, Brinsmead MW, Zhang H-P, Cubis J, Thornton K & Hurt D. Plasma Corticotrophin-Releasing Hormone, B-endorphin and Cortisol Inter-relationships During Human Pregnancy. Acta Endocrinologica, 128:339-344. 1993.
70 Smith R, Chan E-C, Bowman ME, Winthrop JH & Phippard AF. Corticotropin-Releasing Hormone in Baboon Pregnancy. Journal of Clinical Endocrinology & Metabolism, 76(3):1063-1068 1993.
71 Clifton VL, Read MA, Leitch IM, Boura ALA, Robinson PJ & Smith R. Corticotropin-releasing
hormone induced vasodilatation in the human fetal placental circulation.
Journal of Clinical Endocrinology & Metabolism, 79(2):666-669 1994.
72 Sun K, Smith R & Robinson PJ. Basal and KC1 stimulated corticotrophin-releasing
hormone release from human placental syncytiotrophoblasts is inhibited by sodium
nitroprusside.
Journal of Clinical Endocrinology & Metabolism, 79(2):519-524 1994.
73 McLean M, Thompson D, Zhang H-P, Brinsmead M & Smith R. Corticotrophin-releasing hormone and ß-endorphin in labour. European Journal of Endocrinology, 131:167-172 1994.
74 McLean M, Bisits A, Davies J, Woods R, Lowry P & Smith R. A placental clock controlling the length of human pregnancy. Nature Medicine, 1:(5) 460-463 1995.
75 McLean M & Smith R. Cushing's syndrome: how should we investigate in 1995?. The Medical Journal of Australia, 1637 August 1995 153:154.
76 Harte JL, Eifert GH & Smith R. The effects of running and meditation on ß-endorphin, corticotrophin- releasing hormone and cortisol in plasma, and on mood. Biological Psychology, 40:251-265 1995.
77 Clifton VL, Read MA, Leitch IM, Giles WB, Boura ALA, Robinson PJ & Smith
R. Corticotrophin-releasing hormone-induced vasodilatation in the human fetal-placental
circulation: Involvement of the nitric oxide-cyclic guanosine 3',5'-monophosphate-mediated
pathway.
Journal of Clinical Endocrinology & Metabolism, 80: 2888-2893 1995.
78 Clifton VL, Owens PC, Robinson PJ & Smith R. Identification and characterisation of a corticotrophin- releasing hormone receptor in human placenta. European Journal of Endocrinology, 133:591-597 1995.
79 Roe CM, Leitch IM, Boura ALA & Smith R. Nitric oxide regulation of corticotrophin-releasing hormone release from the perfused placenta in vitro. Journal of Clinical Endocrinology and Metabolism 81:2:763-769 1996.
80 Giles WB, McLean M, Davies JJ & Smith R. Abnormal umbilical Artery Doppler Waveforms and Cord Blood Corticotrophin-Releasing Hormone. Obstetrics & Gynaecology, 87:(1)107-11 1996.
81 Clifton, VL, Read MA, Boura AL, Robinson PJ & Smith R. Adrenocorticotropin causes vasodilation in the human fetal-placental circulation. Journal of Clinical Endocrinology & Metabolism, 81(4):1406-10, 1996.
82 Li H, Liu J-P, Smith R & Robinson PJ. Identification of cGMP-dependent protein kinase and its specific substrates in the anterior pituitary. Molecular & Cellular Endocrinology, 122:159-171 1996.
83 Xin Ni, Chan E-C, Fitter J & Smith R. Nitric Oxide Inhibits Corticotropin-Releasing
Hormone Exocytosis but not Synthesis by Cultured Human Trophoblasts
Journal of Clinical Endocrinology and Metabolism, 82(12):4171-4175 1997.
84 Bowman ME, Robinson PJ & Smith R. Atrial Natriuretic Peptide, Cyclic GMP Analogues and Modulation of Guanylyl Cyclase do not Alter Stimulated POMC Peptide Release From Perifused Rat or Sheep Corticotrophs. Journal of Neuroendocrinology, 9:929-936 1997.
85 Leitch IM, Roe CM, Walters WAW, Smith R & Boura ALA. Effect of the L-Arginine
Nitric Oxide Pathway on Human Placental Vascular Tone and Corticotropin-Releasing
Hormone Secretion.
Hypertension in Pregnancy, 16(3):367-378 1997.
86 Chan E-C, Falconer J, Madsen G, Rice KC, Webster E, Chrousos GP & Smith R. A Corticotropin-releasing hormone Type I Receptor Antagonist Delays Parturition in Sheep. Endocrinology, 139:3357-3360 1998.
87 Smith R. Alterations in the hypothalamic pituitary adrenal axis during pregnancy and the placental clock that determines the length of parturition. Journal of Reproductive Immunology, 39:215-220 1998.
88 Smith R & McLean M. The Endocrinology of Pregnancy. Principles of Medical
Biology, Volume 12
Reproductive Endocrinology and Biology, 155-165 1998.
89 Leitch IM, Boura ALA, Botti C, Read MA, Walters WAW & Smith R. Vasodilator
Actions of Urocortin and Related Peptides in the Human Perfused Placenta In
vitro.
Journal of Clinical Endocrinology and Metabolism, 83(12):4510-4513 1998.
90 Smith R, Mesiano S, Chan E-C, Brown S & Jaffe RB. Corticotropin-Releasing Hormone Directly and Preferentially Stimulates Dehydroepiandrosterone Sulfate Secretion by Human Fetal Adrenal Cortical Cells. Journal of Clinical Endocrinology and Metabolism, 83(8):2916-2920 1998.
91 Jaffe RB, Mesiano S, Smith R, Coulter CL, Spencer SJ & Chakravorty A. The regulation and role of fetal adrenal development in human pregnancy. Endocrine Research, (Aug-Nov) 24(3-4):919-26 1998.
92 Bisits A, Madsen G, McLean M, O'Callaghan S, Smith R & Giles W. Corticotropin-releasing hormone: A biochemical predictor of preterm delivery in a pilot randomised trial of the treatment of preterm labour. American Journal of Obstetrics & Gynecology, 178(4):862-866 1998.
93 Majzoub JA, Schulkin J, McGregor JA, Goland RS, Lockwood CJ, Smith R &
Taggart MS. A central theory of preterm and term labor: putative role for corticotropin-releasing
hormone.
American Journal of Obstetrics & Gynecology. Jan;180(1 Pt 3): 232-241 1998.
94 Smith R. The Timing of Birth. Scientific American March, 68-75 1999.
95 Smith R. Corticotropin-releasing hormone and the fetoplacental clock: An
Australian perspective.
American Journal of Obstetrics and Gynecology, Jan;180(1 Pt 3): 269-271 1999.
96 Keller PA, Bowman M, Dang KH, Garner J, Leach SP, Smith R & McCluskey
A. Pharmacophore Development for Corticotrophin-Releasing Hormone: New Insights
into Inhibitor Activity.
Journal of Medicinal Chemistry, 42(13):2351-2357 1999.
97 Smith R, Wicking EJ, Bowman ME, Belleoud A, Dubreuil G, Davies JJ &
Madsen G. Corticotropin-Releasing Hormone in Chimpanzee and Gorilla pregnancies.
Journal of Clinical Endocrinology and Metabolism, (Aug); 84/8:2820-2825 1999.
98 McLean M, Bisits A, Davies J, Walters W, Hackshaw A, De Voss K & Smith R. Predicting risk of preterm delivery by second trimester measurement of maternal plasma Corticotropin-releasing hormone and Alpha-fetoprotein. American Journal of Obstetrics & Gynaecology, (Sep); 181(1):207-215 1999.
99 Leung TN, Chung T, Madsen G, McLean M, Chang AMZ & Smith R. Elevated
mid-trimester maternal corticotrophin-releasing hormone levels in pregnancies
destined to deliver preterm before 34 weeks.
British Journal of Obstetrics and Gynaecology, (Oct); 106:1041-1046 1999.
100 McLean M & Smith R. Corticotropin-Releasing Hormone in Human Pregnancy
and Parturition.
Trends in Endocrinology and Metabolism, Vol 10 (5):174-178 1999.
101 Smith R, Chan E-C, Mesiano S, Nicholson R, Cheng Y-H, Bowman M, Clifton V, Madsen G, Fitter JT, Giles W & Bisits A. Regulation of Parturition: The Role of CRH. (Chapter 24) Hormones and Women's Health: The Reproductive Years. Vol 1. (2000) Harwood Academic Publishers imprint, part of The Gordon and Breach Publishing Group.
102 Giles W, Bisits A, Knox M, Madsen G & Smith R. The effect of fetal
fibronectin testing on admissions to a tertiary maternal-fetal medicine unit
and cost savings.
American Journal of Obstetrics & Gynaecology, V182 (2):439-442. 2000
103 Cheng Y-H, Nicholson RC, King B, Chan E-C, Fitter JT & Smith R. Corticotropin-Releasing
Hormone Gene Expression in Primary Placental Cells is Modulated by Cyclic Adenosine
3',5'-Monophosphate.
Journal of Clinical Endocrinology and Metabolism, (Mar); 85/3:1239-1244 2000.
104 Cheng Y-H, Nicholson RC, King B, Chan E-C, Fitter JT & Smith R. Glucocorticoid
stimulation of corticotropin-releasing hormone gene expression requires a 3',5'-cyclic
AMP regulatory element in human primary placental cytotrophoblast cells.
Journal of Clinical Endocrinology and Metabolism, (May); 85/5:1937-1945 2000.
105 McLean M, Bowman M, Clifton V, Smith R & Grossman AB. Expression of
the Heme Oxygenase - Carbon Monoxide Signalling system in Human Placenta.
Journal of Clinical Endocrinology and Metabolism, (Jun); 85/6:2345-2349 2000.
106 Smith R. Futures. Nature (406) 567 2000.
107 Leung TN, Chung TKH, Madsen G, Lam CWK, Lam PKW, Walters WAW & Smith R. Analysis of mid-trimester corticotrophin-releasing hormone and "-fetoprotein concentrations for predicting pre-eclampsia. Human Reproduction, 15/8:1813-1818 2000
108 Donoghue JF, Leitch IM, Boura ALA, Walters WAW, Giles WB, Smith R &
Read MA. Fetal placental vascular responses to corticotropin-releasing hormone
in vitro. Effects of variation in oxygen tension.
Placenta 21(7):711-717 2000
109 Clifton VL, Qing G, Murphy VE, Schwartz J, Madsen G & Smith R. Localisation and characterisation of urocortin during human pregnancy. Placenta 21(8):782-788 2000
110 Chan E-C & Smith R. Lessons in labour. Human parturition on the beach
conference (26th - 28th October 2000).
Trends in Endocrinology and Metabolism 3(12):44-46 2001
111 McLean M & Smith R. Corticotrophin-releasing hormone and human parturition. Reproduction. 121/4:493-501. 2001
112 King BR, Smith R & Nicholson R. The regulation of human corticotrophin-releasing hormone gene expression in the placenta. Peptides 22(11):1941-1947. 2001
113 Zarzycki PK & Smith R. Separation of steroids using temperature dependent inclusion chromatography. Journal Chromatography A, 912 2001 pp. 45-52. 2001
114 Bowman M, Lopata A, Jaffe RB, Golos TG, Wickings J & Smith R. Corticotropin-releasing hormone-binding protein in primates. American Journal of Primatology, 53:123-130 2001
115 Leung TN, Chung TKH, Madsen G, Lam P, Sahota D & Smith R. Rate of rise
in maternal plasma corticotrophin-releasing hormone and its relation to gestational
length.
British Journal of Obstetrics & Gynaecology, 108(5):527-532. 2001
116 Smith R, Editor. Frontiers of Hormone Research (series) "The Endocrinology of Parturition - Basic Science and Clinical Application" Vol 27 (19 Chapters, 316 pages). Publisher: S. Karger AG. April 2001
117 Clifton VL, Giles WB, Smith R, Bisits AT, Hempenstall P, Kessell C &
Gibson P. Alterations of placental vascular function in asthmatic pregnancies.
American Journal of Respiratory Medicine and Critical Care Medicine. 164(4):546-553
2001
118 McGrath SA & Smith R. Corticotrophin-releasing hormone and parturition.
Clinical Endocrinology 55:593-595. 2001
119 King BR, Nicholson R & Smith R. Placental corticotrophin-releasing hormone, local effects and fetomaternal endocrinology. Stress 4(4):219-233 2001
120 Clifton VL, Crompton R, Smith R & Wright IMR. Microvascular effects
of corticotropin-releasing hormone in human skin vary in relation to gender.
Journal of Clinical Endocrinology and Metabolism, (Jan); 87/1:267-270 2002.
121 O'Dwyer DT, Clifton V, Hall A, Smith R, Robinson PJ & Crock PA. Pituitary
autoantibodies in lymphocytic hypophysitis target both gamma- and alpha- enolase
- A link with pregnancy?
Archives of Physiology and Biochemistry Apr, 110(1-2):94-98 2002
122 Schwartz J, Revskoy S, Redei E, Clifton V, Smith R & Cherny R. Corticotrophs
and peptides.
Archives of Physiology and Biochemistry Apr, 110(1-2):146-153 2002
123 Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG & Clifton VL. Reduced 11b-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma. Journal of Clinical Endocrinology and Metabolism, (Apr); 87/4:1660-1668 2002.
124 Zarzycki PK, Kulhanek KM & Smith R. Chromatographic behaviour of selected
steroids and their inclusion complexes with b-cyclodextrin on octadecylsilica
stationary phases with different carbon loads.
Journal of Chromatography A, 955 pp. 71-78. 2002
125 Holloway AC, Howe DC, Chan G, Clifton VL, Smith R & Challis RG. Urocortin:
A mechanism for the sustained activation of the HPA axis in the late gestation
ovine fetus?
American Journal of Physiology - Endocrinology and Metabolism. July 283(1):165-171
2002 .
126 Chan EC, Fraser S, Yin S, Yeo G, Kwek K, Fairclough RJ & Smith R. Human myometrial genes are differentially expressed in labour. Journal of Clinical Endocrinology and Metabolism, (Jun); 87/6:2435-2441 2002.
127 McGrath S, McLean M, Smith D, Bisits A, Giles W & Smith R. Maternal
plasma corticotropin-releasing hormone trajectories vary depending on the cause
of preterm delivery.
American Journal of Obstetrics & Gynecology. 186(2):257-260 2002
128 Mesiano S, Chan E-C, Fitter JT, Kwek K, Yeo G & Smith R. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor-A expression in the myometrium. Journal of Clinical Endocrinology and Metabolism, (Jun); 87/6:2924-2930 2002.
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