Gemma Madsen BSc (Honours) (Sydney), MSc (Sydney)
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Research
Officer / PhD Student Endocrine
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Postal Address.
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Current Research
Co-ordinator of the Randomised Nitric Oxide Tocolysis Trial (RNOTT) and Project Officer of the Targeted Institutional Links (TIL) Program. The study was a randomised multi-centre controlled trial of transdermal nitroglycerine versus conventional treatment (intravenous salbutamol) for preterm labour including follow-up of the infants to 18 months. The main objective of the TIL Program was to link major obstetric centres in South East Asia with The Mothers and Babies Research Centre to establish a South East Asian Australasian Preterm Labour Study Group which made this multi-centre trial possible. The role of co-ordinator included establishing the database for the trial, data acquisition and analysis and assay of corticotrophin releasing hormone. As Project Officer on the TIL Program I was responsible for liaison between the different institutions, maintaining a central computerised database of pregnancies and their outcomes and organising annual conferences between the centres involved. The trial has been completed and the data published.My PhD research is on estrogen and progesterone actions in human parturition with the main focus on progesterone withdrawal, under the supervision of Professor Roger Smith and Dr Sam Mesiano (Case Western Reserve University, Cleveland).
Memberships
Endocrine Society of Australia
Perinatal Society of Australia & New ZealandPublications
Rowe PB, Madsen G, McCairns E and Sauer D. A multienzyme complex for de novo purine biosynthesis. Adv. Exp. Med. Biol. 76A (Purine Metab. Man - 2, Part A) 13-18 1977.
Powis D and Madsen G. Unsuitability of the 86Rb+ uptake method for estimation of (Na+ + K+) - ATPase activity in innervated tissues. Biochimica et Biophysica Acta 861: 251-258 1986.
Powis D, Madsen G and Torok T. Augmentation of the indirect symphathoimetic action of tyramine by cardioactive steroids is a consequence of elevated intracellular sodium. Naunyn- Schmiedeberg's Arch Pharmacol 337: 273-278 1988.
Thomson M, Chan E-C, Falconer J, Madsen G and Smith R. Secretion of corticotrophin-releasing hormone by superfused human placental fragments. Gynecol. Endocrinol. 2: 87-100 1988.
Chan E-C, Thomson M, Madsen G, Falconer J and Smith R. Differential Processing of corticotrophin-releasing hormone by the human placenta and hypothalamus. Biochem. Biophys. Res, Commun. 153(3): 1229-1235 1988.
Falconer J, Chan E-C, Madsen G, Thomson M, Davies J and Smith R. Secretion of - endorphin into the maternal circulation by uteroplacental tissues in response to hypoglycaemic stress. J. Endocrinol. 118: R5-R8 1988.
Chan E-C, Thomson M, Madsen G, Boettcher B, Falconer J and Smith R. Large molecular weight immunoreactive corticotrophin-releasing hormone has bioactivity on superfused ovine pituitary cells. J. Neuroendocrinol. 2(1): 95-101 1990.
Thomson M, Chan E-C, Falconer J, Madsen G and Smith R. Desensitization of superfused isolated ovine anterior pituitary cells to human corticotrophin-releasing factor. J. Neuroendocrinol. 2(2): 181-187 1990.
Thomson M, Chan E-C, Davies J, Falconer J, Madsen G, Geraghty S and Smith R. Intracellular mechanisms governing the acute phase of B-endorphin secretion from the corticotrope in vitro. Neurosci. Letts. 110: 343-348 1990.
Madsen G, Chan E-C, Falconer J, Ho KY and Smith R. Reverse haemolytic plaque assay study of corticotrophin-releasing hormone and arginine vasopressin interaction in ovine corticotrophs. Neuroendocrinol. 3(2): 193-197 1991.
Smith R, Chan E-C and Madsen G. The maternal hypothalamo-pituitary-adrenal axis in pregnancy and the puerperium. In: Stress and Reproduction, (Eds) Sheppard KE, Boublik JH, Funder JW. Serono Symposia Publications from Raven Press 86, 73-92 1992.
Husband AJ, Lin W, Madsen G and King M. A conditioning model for immunostimulation: Enhancement of the antibody response to ovalbumin by behavioural conditioning in rats. In: Psychoimmunology, CNS-Immune Interaction, (Ed) Husband AJ. CRC Press INC. 139-148 1993.
Dunkley ML, Madsen G and Husband AJ. Heterogeneity of helper T subsets in Peyer's patches. Immunology Letters. 37: 181-186 1993.
Batey R, Cao Q, Madsen G, Pang G, Russell, Clancy R. Decreased tumor necrosis factor- and interleukin-1 production from intrahepatic mononuclear cells in chronic ethanol consumption and upregulation by endotoxin. Alcohol Clin Exp Res. 22(1):150-156 1998.
Batey R, Madsen G. The carbohydrate-deficient transferrin test in hospital practice. Drug Alcohol Rev. 17:105-109 1998.
Chan EC, Falconer J, Madsen G, Rice KC, Webster EL, Chrousos GP, Smith R. A corticotropin releasing hormone type receptor antagonist delays parturition in Sheep. Endocrinology. 139(7):3357-3360 1998.
Bisits A, Madsen G, McLean M, O'Callaghan S, Smith R, Giles W. CRH - A biochemical predictor of preterm delivery in a pilot randomised trial of the treatment of preterm labour. American Journal of Obstetrics and Gynecology. 178(4):862-866 1998.
Leung TN, Chung T, Madsen G, McLean M, Chang AMZ, Smith R. Elevated mid-trimester maternal corticotrophin-releasing hormone levels in pregnancies destined to deliver preterm. British Journal of Obstetrics and Gynaecology 106:1041-1046 1999.
Smith R, Wicking EJ, Bowman ME, Belleoud A, Dubreuil G, Davies JJ, Madsen G. Corticotropin-releasing hormone in chimpanzee and gorilla pregnancies. Journal of Clinical Endocrinology and Metabolism. 84(8):2820-2825 1999.
Smith R, Chan E-C, Mesiano S, Nicholson R, Cheng Y-H, Bowman M, Clifton V, Madsen G, Fitter JT, Giles W, Bisits A. Regulation of Parturition: The Role of CRH. (Chapter 24) Hormones and Women's Health: The Reproductive Years. Vol 1. (2000) Harwood Academic Publishers, part of The Gordon and Breach Publishing Group.
Giles W, Knox M, Madsen G, Bisits A, Smith R. The effect of fetal fibronectin usage on admissions to a tertiary maternal fetal medicine unit and cost savings. American Journal of Obstetrics and Gynecology 182(2):439-442 2000.
Clifton VL, Qing G, Murphy VE, Schwartz J, Madsen G, Smith R. Localisation and characterisation of urocortin during human pregnancy. Placenta. 21(8):782-788 2000.
Leung TN, Chung TK, Madsen G, Lam CW, Lam PK, Walters WA, Smith R. Analysis of mid-trimester corticotrophin-releasing hormone and alpha-fetoprotein concentrations for predicting pre-eclampsia. Human Reproduction. 15(8):1813-1818 2000.
Leung TN, Chung TKH, Madsen G, Lam P, Sahota D, Smith R. Elevated rate of increase of maternal plasma corticotrophin-releasing hormone in pregnancies complicated by preterm delivery. British Journal of Obstetrics and Gynaecology. 108:618-622 2001.
Gu Q, Clifton VL, Schwartz J, Madsen G, Sha J, Smith R. Characterization of urocortin in human pregnancy. Chin Med J, 114, 6, pp.618-622, 2001.
Madsen G, Zakar T, Ku CY, Sanborn B, Smith R, Mesiano S. Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: Evidence for prostaglandin-induced functional progesterone withdrawal. Journal of Clinical Endocrinology and Metabolism. 89(2): 1010-1013, 2004.
Madsen G, Zakar T, Manuelpillai U, Wallace E, Kwek K, Yeo GSH, Smith R, Mesiano S. Intracrine control of estrogen action in human gestational tissues at parturition. Journal of the Society for Gynecologic Investigation, 11: 213-219, 2004.Bisits A, Knox M, Gill A, Smith R, Yeo G, Kwek K, Daniel M, Leung TN, Cheung K, Chung T, Jones I, Toohill J, Tudehope D and Giles W. The Randomised Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labour. American Journal of Obstetrics and Gynecology, 191:683-690, 2004.
Gill A, Madsen G, Knox M, Bisits A, Giles W, Tudehope, D, Rogers Y, Smith R. Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches. American Journal of Obstetrics and Gynecology, 195(2):484-7, 2006.
Madsen G, MacIntyre, DA, Mesiano S and Smith R. Progesterone Receptor or Cytoskeletal Protein? Reproductive Sciences - in press, 2007.
Published Abstracts
Madsen G, Blades Q and Rowe PB. The purine biosynthetic enzyme complex. Proceedings of the Australian Biochemical Society 8, 1. 1975.
Powis DA and Madsen G. Characteristics of tyramine - evoked noradrenaline release from nerve terminals in dog saphenous vein. Neurosci. Lett. Supp. 23, S73 1986.
Owens P, Smith R, Owens J, Chan E-C, Madsen G, Lovelock M, Kind K, Falconer J and Robinson JS. Plasma met-enkephalin and B-endorphin during acute hypoxia in fetal sheep. Endocrine Society of Australia, Sydney, Australia, August 24, 1987.
Mooney P, Thomson M, Chan E-C, Madsen G and Smith R. Control of human placental lactogen secretion by dopamine. Endocrine Society of Australia, Sydney, Australia, August 24, 1987.
Chan E-C, Lovelock M, Thomson M, Madsen G and Smith R. Large molecular weight corticotrophin-releasing hormone in the placenta. Endocrine Society of Australia, Sydney, Australia, August 24, 1987.
Thomson M, Chan E-C, Madsen G, Falconer J and Smith R. Secretion of protein hormones from superfused placental fragments. Eighth International Congress of Endocrinology, Satellite Symposium on Placental Protein Hormones, Kobe, Japan, July 1988.
Chan E-C, Thomson M, Madsen, Falconer J and Smith R. Placental large molecular weight immunoreactive corticotrophin-releasing hormone has bioactivity. Eighth International Congress of Endocrinology, Satellite Symposium on Placental Protein Hormones, Kobe, Japan, July 1988.
Falconer J, Chan E-C, Thomson M, Madsen G and Smith R. The ovine placenta contains corticotrophin-releasing hormone and is stress responsive. Eighth International Congress of Endocrinology, Satellite Symposium on Placental Protein Hormones, Kobe, Japan, July 1988.
Chan E-C, Thomson M, Madsen G, Falconer J and Smith R. Differential post-transitional processing of CRH in the human hypothalamus and the placenta. Eighth International Congress of Endocrinology, Kyoto, Japan, July, 1988.
Thomson M, Chan E-C, Falconer J, Madsen G and Smith R. Secretion of CRH by superfused human placental fragments. Eighth International Congress of Endocrinology, Kyoto, Japan, July, 1988.
Falconer J, Chan E-C, Thomson M, Madsen G and Smith R. Effect of maternal hypoglycaemia on fetal and maternal plasma B-endorphin. Eighth International Congress of Endocrinology, Kyoto, Japan, July, 1988.
Thomson M, Chan E-C, Falconer J, Madsen G and Smith R. Corticotrophin-releasing hormone in the pregnant woman. Proceedings of the Australian Biochemical Society 20 1988.
Chan E-C, Suggit J, Madsen G, Davies J, Thomson M, Falconer J and Smith R. The nature of human placental B-endorphin immunoreactivity. The Endocrine Society 71st Annual Meeting, Seattle, Washington, June 1989.
Thomson M, Chan E-C, Falconer J, Madsen G and Smith R. Desensitization of superfused isolated anterior ovine pituitary cells to stimulators of B-endorphin secretion. Second International Pituitary Congress, Palm Desert, California. June 1989.
Chan E-C, Suggit J, Thomson M, Madsen G, Falconer J, Davies JJ and Smith R. Different forms of B-endorphin-like peptides in human placental extracts. The Australian Society for Medical Research, Adelaide, Australia. December 1989.
Thomson M, Chan E-C, Falconer J, Davies JJ and Smith R. Desensitization of superfused isolated ovine anterior pituitary cells to human corticotrophin-releasing factor. Endocrine Society of Australia, Melbourne, Australia. September 1989.
Madsen G, Chan E-C, Thomson M, Davies J, Falconer J, Ho KY and Smith R. Reverse haemolytic plaque assay study of AVP-CRH synergism in ovine corticotrophs. Endocrine Society of Australia, Melbourne, Australia. September 1989.
Thomson M, Chan E-C, Falconer J, Madsen G, Davies J and Smith R. Intracellular messenger systems in the corticotrophs of the anterior pituitary. Endocrine Society of Australia, Melbourne, Australia. September 1989.
Davies J, Falconer J, Chan E-C, Thomson M, Madsen G and Smith R. Regionall variations in B-endorphin release from superfused ovine placenta. Endocrine Society of Australia, Melbourne, Australia. September 1989.
Chan E-C, Thomson M, Madsen G, Davies J, Falconer J and Smith R. Superfused ovine pituitary cells dissociate large molecular weight CRH. Endocrine Society of Australia, Melbourne, Australia. September 1989.
Smith R, Thomson M, Zhang H-P, Falconer J, Chan E-C, Davies J, Madsen G and Suggit J. Activation and desensitization of intracellular signalling mechanisms controlling luteinizing hormone release from superfused isolated ovine anterior pituitary cells. Second International Congress of Neuroendocrinology, Bordeaux, France. June 1990.
Suggit J, Chan E-C, Madsen G, Zhang H-P and Smith R. Acetylated B-endorphin in the human placenta. The Australian Society for Medical Research, Lorne, Victoria. December 1990.
Madsen G and Smith R. Human placental cells in short term culture secrete corticotrophin- releasing hormone: detection by reverse haemolytic plaque assay. Twenty ninth National Scientific Conference of the Australian Society for Medical Research, Lorne, Victoria. December 1990.
Dunkley ML, Madsen G and Husband AJ. Helper T cell subsets in Peyer's patches after intestinal immunisation. Twenty-first Annual Scientific Meeting of the Australian Society for Immunology Inc., The University of Western Australia, Perth WA. December 1991.
Madsen G and Batey RG. Carbohydrate Deficient Transferrin: Is it a useful test in a Gastroenterology practice? Australian Gastroenterology Week, Sydney NSW. September 1994. J. Gastro. Hepatol. 9(5): A83 1994.
Batey RG, Cao Q, Madsen G, Pang G and Clancy R. Intrahepatic lymphocyte production of IL-1, IL-6 and TNF- in alcoholic liver disease in the rat. Australian Gastroenterology Week, Perth, WA. October 1995. J. Gastro. Hepatol. 10(2): A45 1995.
Madsen G and Batey RG. A retrospective study of Hepatitis C (HCV) and liver disease in the Hunter Region of NSW. Australian Gastroenterology Week, Perth, WA. October 1995. J. Gastro. Hepatol. 10(2): A25 1995.
Madsen G, McLean M, Giles W, Bisits A and Smith R. Maternal corticotrophin releasing hormone levels in preterm labour treated with transdermal nitroglycerine or salbutamol. Thirty ninth Annual Scientific Meeting of the Endocrine Society of Australia, Sydney, NSW October 1996. Proc Endo Soc Aust 39: A92 1996.Madsen G,McLean M, Bisits A, O'Callaghan S, Giles W, Smith R. Maternal corticotrophin releasing hormone concentrations predict outcome of treatment for preterm labour. Seventy ninth Annual Meeting of the Endocrine Society, Minneapolis, Minnesota. June 1997.
Chan EC, Falconer J, Madsen G, Read M, Chrousos G, Rice K, Smith R. Antagonism of corticotropin releasing hormone delays parturition in sheep. Eightieth Annual Meeting of the Endocrine Society, New Orleans, Louisiana. June 1998.
Leung TN, Chung TK, Hin LY, Chang A, Madsen G, Walters W, Smith R. Maternal corticotrophin releasing hormone (CRH) at 16-20 weeks in the prediction of spontaneous preterm labour. Twenty eighth British Congress of Obstetrics and Gynaecology, Harrowgate, UK. July 1998.
Leung TN, Chung TK, Hin LY, Chang A, Madsen G, Walters W, Smith R. Maternal corticotrophin releasing hormone (CRH) at 16-20 weeks in the prediction of pre-eclampsia. Twenty eighth British Congress of Obstetrics and Gynaecology, Harrowgate, UK. July 1998.
Mesiano S, Madsen G. Regulation of estrogen action during human pregnancy and parturition: Metabolism by target tissues to more or less active forms. Third annual congress of the Perinatal Society of Australia and New Zealand, Melbourne. March 1999.
Mesiano S, Smith R, Madsen G. Regulation of estrogen action during human pregnancy and parturition: Metabolism by target tissues to more or less active forms. Eighty first Annual Meeting of the American Endocrine Society, San Diego, California. June 1999.
Madsen G, Mesiano S. Regulation of estrogen action during human pregnancy and parturition by differential expression of 17 hydroxysteroid dehydrogenase enzymes in estrogen target tissues. Annual Meeting of the Endocrine Society of Australia, Melbourne. September 1999.
Erdonmez T, Madsen G, Smith R, Mesiano S. Progesterone receptor expression and localization in laboring and non-laboring human fetal membranes. Proceedings of the Endocrine Society of Australia, 44: 262, 2001.
Welsh T, Madsen G, Mesiano S, Walters WAW, Zakar T. Prostaglandin H synthase type-2 (PGHS-2) and prostaglandin dehydrogenase type-1 (PGDH) expression in gestational tissues of the guinea pig. Proceedings of the Endocrine Society of Australia, 44: 431, 2001.
Giles W, Knox M, Madsen G, Bisits A, Gill A, Smith R, Jones I, Kwek K, Leung D. The randomised nitric oxide tocolysis trial. American Journal of Obstetrics and Gynecology, 184 (1): S6, 2001.
Madsen G, Yeo G, Kwek K, Smith R, Mesiano S. Role of local estrogen metabolism in the control of estrogen action in human parturition. Proceedings of the Endocrine Society of Australia, 45: 102, 2002.
Madsen G, Zakar T, Smith R, Mesiano S. Progesterone Receptor Expression is Modulated by Prostaglandins in Human Myometrial Cells. Proceedings of the Endocrine Society of Australia, 46: 112, 2003.
Madsen G, Erdonmez T, Smith R, Zakar T, Mesiano S. Second Messenger Control of Progesterone Receptor Expression in Human Myometrial Cells. Proceedings of the Endocrine Society of Australia, 46: 172, 2003.
Madsen G, Sanborn B, Zakar T, Mesiano S. Modulation of progesterone receptor expression by prostaglandins in pregnant human myometrial cells: Evidence that prostaglandins induce progesterone withdrawal. Journal of the Society for Gynecologic Investigation, 10 (2) Supplement: 188A, 2003. (recipient of The Wyeth-Ayerst President's Presenter Award).
Madsen G, Zakar T, Chan E-C, Yeo G, Kwek K, Mesiano S. Prostaglandin Receptor Expression in Human Myometrium Before and After the Onset of Labour: Journal of the Society for Gynecologic Investigation, 11 (2) Supplement: 302A, 2004.
Madsen G, Mesiano S, Tyson E, Read M and Smith R. Modulation of Progesterone Receptor Expression by Corticotrophin Releasing Hormone in Human Myometrial Cells. Endocrine Journal 52 (Supplement): 92, 2005.
Erdonmez T, Madsen G, Zakar T, Smith R and Mesiano S. Progesterone Receptor Protein Expression in Human Fetal Membranes and Myometrium with the Onset of Labour. Endocrine Journal 52 (Supplement): 91, 2005.
Madsen G, Mesiano S and Smith R. Effect of Oxytocin on Progesterone Receptor Isoform Expression in Human Myometrial Cells - to be presented at the SGI (Society for Gynecologic Investigation) 1st International Summit on Preterm Birth - Siena, Italy, November 10-12, 2005.
Erdonmez T, Madsen G, Zakar T, Smith R and Mesiano S. Progesterone Receptor Splice Variant and Isoform Expression in Human Pregnancy Myometrial Cells: Novel Targets for Genomic and Non-Genomic Progesterone Actions - to be presented at the SGI (Society for Gynecologic Investigation) 1st International Summit on Preterm Birth - Siena, Italy, November 10-12, 2005.
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