Dr
Eng Cheng Chan B.Sc (Hon) (Newcastle) Ph.D (Newcastle)
Contact Details
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Senior Research
Officer
Endocrine Unit, Mothers and Babies
Postal Address.
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 .........61
(0) 249 214370
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Memberships
Endocrine Society of Australia.
Research Interests
Interested in doing an honours research year with us? Check-out
the projects available here.
Publications
Young JI, Otero V, Cerdan MG, Falzone
TL, Chan EC, Low MJ, Rubinstein M. Authentic cell-specific and developmentally
regulated expression of pro-opiomelanocortin genomic fragments in hypothalamic
and hindbrain
neurons of transgenic mice. J
Neurosci 1998 18:6631-40
Smith R, Mesiano S, Chan EC, Brown S, Jaffe RB. Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. J Clin Endocrinol Metab. 1998 83:2916-20
Chan EC, Falconer J, Madsen G, Rice KC, Webster EL, Chrousos GP, Smith RA corticotropin-releasing hormone type I receptor antagonist delaysparturition in sheep. Endocrinology 1998 139:3357-60
Ni X, Chan EC, Fitter JT, Smith R. Nitric
oxide inhibits corticotropin-releasing hormone exocytosis but not
synthesis by cultured human trophoblasts.
J
Clin Endocrinol Metab 1997 82:4171-5
Rubinstein M, Mogil JS, Japon M, Chan EC, Allen RG, Low MJ. Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. Proc Natl Acad Sci U S A 1996 93:3995-4000
Chan EC, Smith R, Lewin T, Brinsmead MW, Zhang HP, Cubis J, Thornton K, Hurt D. Plasma corticotropin-releasing hormone, beta-endorphin and cortisol inter-relationships during human pregnancy. Acta Endocrinol (Copenh) 1993 128:339-44
Smith R, Chan EC, Bowman ME, Harewood WJ, Phippard AF. Corticotropin-releasing hormone in baboon pregnancy. J Clin Endocrinol Metab 1993 76:1063-8
Chan EC, Smith R. Beta-endrophin immunoreactivity during human pregnancy. J Clin Endocrinol Metab 1992 75:1453-8
Davies JJ, Falconer J, Zhang HP, Chan EC, McLean M, Smith R. Perifused ovine placental tissue secretes beta-endorphin immunoreactivity. Reprod Fertil Dev 1991 3:397-404
Chan EC, Brinsmead MW, Chen SE, Nanra R, Simm B, McLean M, Smith R. Urinary corticotropin-releasing hormone immunoreactivity is elevated during human pregnancy. Gynecol Endocrinol 1990 4:233-44
Thomson M, Chan EC, Davies J, Falconer J, Madsen G, Geraghty S, Smith R. Intracellular mechanisms governing the acute phase of beta-endorphin secretion from the corticotrope in vitro. Neurosci Lett 1990 14;110:343-8
Smith R, Cubis J, Brinsmead M, Lewin T, Singh B, Owens P, Chan EC, Hall C, Adler R, Lovelock M, et al. Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium. J Psychosom Res 1990 34:53-69
Owens PC, Owens JA, Lovelock M, Chan EC, Falconer J, Robinson JS, Smith R. Restriction of placental growth in sheep enhances placental metabolism of fetal beta-endorphin-like immunoreactivity.J Dev Physiol 1989 11:63-71
Smith R, Lovelock M, Owens PC, Chan EC, Falconer J. The effect of repetitive haemorrhage on plasma cortisol, beta-endorphin and N-terminal pro-opiomelanocortin in conscious sheep. Horm Metab Res 1988 20:612-5
Falconer J, Chan EC, Madsen G, Thomson M, Davies J, Smith R. Secretion of beta-endorphin into the maternal circulation by uteroplacental tissues in response to hypoglycaemic stress. J Endocrinol 1988 118:R5-8
Chan EC, Thomson M, Madsen G, Falconer J, Smith R. Differential processing of corticotrophin-releasing hormone by the human placenta and hypothalamus. Biochem Biophys Res Commun 1988 30 153:1229-35
Thomson M, Chan EC, Falconer J, Madsen G, Smith R. Secretion of corticotropin-releasing hormone by superfused human placental fragments. Gynecol Endocrinol 1988 2:87-100
Owens PC, Chan EC, Lovelock M, Falconer J, Smith R. Immunoreactive methionine-enkephalin in cerebrospinal fluid and blood plasma during acute stress in conscious sheep. Endocrinology 1988 122:311-8
Owens PC, Smith R, Brinsmead MW, Hall C, Rowley M, Hurt D, Lovelock M, Chan EC, Cubis J, Lewin T. Postnatal disappearance of the pregnancy-associated reduced sensitivity of plasma cortisol to feedback inhibition. Life Sci 1987 41:1745-50
Martyn P, Smith R, Owens PC, Lovelock M, Chan EC. Immunoreactive beta-endorphin and pro-gamma-melanotropin in the peripheral circulation during the menstrual cycle. Asia Oceania J Obstet Gynaecol 1987 13:345-50(no abstract avialable)
Smith R, Owens PC, Lovelock M, Chan EC, Falconer J. Acute hemorrhagic stress in conscious sheep elevates immunoreactive beta-endorphin in plasma but not in cerebrospinal fluid. Endocrinology 1986 118:2572-6
Owens P, Lovelock M, Chan EC, Falconer J, Ling N, Smith R. Secretion of N-terminal pro-opiomelanocortin-derived peptides in response to acute haemorrhagic stress in conscious sheep. Biochem Biophys Res Commun 1985 133:648-53
Meet the other Senior Research Staff members
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(0) 249 214394
