Dr Andrew Bisits MBBS (Sydney) FRANZCOG (RCOG) Dip Clin Epidem (Newcastle) Master Med Statistics (Newcastle)
Contact Details
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Senior
Lecturer & Director of Obstetrics Reproductive
Medicine
Postal Address.
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.........61 (0) 249 214392
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Statement
of Research Achievment
Dr Andrew Bisits is an academic obstetrician with training in epidemiology and biostatistics. He has been involved in a wide range of research projects to which he has made major contributions particularly in the area of study design and data analysis. An important aspect of his work has been in the area of preterm delivery. He was a significant contributor to the design, conduct and analysis of the Randomised Trial Of Transdermal Nitrates versus ? sympathomimetics, which our group has recently completed. Dr Bisits was a chief investigator in this NHMRC multicentre trial. This trial produced a number of key findings that have been published. Dr Bisits has subsequently provided much of the design input for our current NHMRC trial comparing nifedipine alone versus nifedipine plus refocoxib (Cox2 inhibitor) in preterm labour. This trial will use a multicentre, group sequential design not previously used in trial of therapy for preterm labour. Andrew is involved in many other research projects undertaken by members of the program. He provided the data analysis of the maternal plasma CRH concentrations that lead to the identification of the placental biological clock that is thought to determine gestational length in the human. He also undertook the data analysis of fetal fibronectin results that confirmed the strong negative predictive value of this test and the cost savings associated with its clinical use. He has undertaken the design and analysis of data on urine metalloprotease testing for the prediction of preterm delivery. Andrew is the major statical and epidemiological consultant for the Mothers and Babies Research Centre. He is currently undertaking Causal Modeling approaches to the analysis of data from epidemiological and more basic biological studies performed by group members.
Memberships
Publications
(1999-2003)
REFEREED JOURNAL ARTICLES
* Five best publications*1. Read MA, Leitch IM, Giles WB, Bisits AM, Boura AL, Walters WA. (1999) U46619-mediated vasoconstriction of the fetal placental vasculature in vitro in normal and hypertensive pregnancies. J Hypertens. 17(3):389-96.
*2. McLean M, Bisits A, Davies J, Walters W, Hackshaw A, De Voss K, Smith R. (1999) Predicting risk of preterm delivery by second-trimester measurement of maternal plasma corticotropin-releasing hormone and alpha-fetoprotein concentrations. Am J Obstet Gynecol.181(1):207-15.
3. Giles W, Bisits A, Knox M, Madsen G, Smith R.(2000) The effect of fetal fibronectin testing on admissions to a tertiary maternal-fetal medicine unit and cost savings. Am J Obstet Gynecol. 182(2):439-42.
*4. Giles W, Bisits A, O'Callaghan S. (2000) The Doppler assessment in multiple pregnancy study (DAMP) and metaanalysis of Doppler and twins. Am J Obstet Gynecol. 182:S17.
5. Clifton VL, Giles WB, Smith R, Bisits AT, Hempenstall PA, Kessell CG, Gibson PG. (2001) Alterations of placental vascular function in asthmatic pregnancies. Am J Respir Crit Care Med. 164(4):546-53.
*6. Giles W, Knox M, Madsen G, Bisits A, Gill A, Smith R, Jones, Kwek K, Leung D. (2001) The randomized nitric oxide tocolysis trial. Am J Obstet Gynecol. 184:S6.
1. Kwek K, Read MA, Khong TY, Bisits AT, Walters WA. (2001) Vasoactive effects of 8-epi-prostaglandin F(2alpha)in isolated human placental conduit and resistance blood vessels in vitro. Placenta 22(6):526-33.
8. Cole S, Smith R, Bisits A. (2001) Pharmacotherapy for preterm labour. Front Horm Res. 27:279-307.
9. McGrath S, McLean M, Smith D, Bisits A, Giles W, Smith R. (2002) Maternal plasma corticotropin-releasing hormone trajectories vary depending on the cause of preterm delivery. Am J Obstet Gynecol. 186(2):257-60.
10. Giles W, O'Callaghan S, Cole S, Bisits A. (2002) Triplet pregnancy complicated by feto-feto-fetal transfusion with very rapid deterioration and fetal demise in all three triplets. Aust N Z J Obstet Gynaecol. 42(4):408-9.
11. Crompton R, Clifton VL, Bisits AT, Read MA, Smith R, Wright IM. Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways. J Clin Endocrinol Metab. 2003 88(11):5427-32.
12. Giles W, Bisits A, O'Callaghan S, Gill A. The Doppler assessment in multiple pregnancy randomised controlled trial of ultrasound biometry versus umbilical artery Doppler ultrasound and biometry in twin pregnancy. BJOG. 2003 110(6):593-7.
13. Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Bisits AM, Kessell CG, Clifton VL. (2003) Maternal asthma is associated with reduced female fetal growth. Am J Respir Crit Care Med. 68(11):1317-23.
14. Harris G, Connor L, Bisits A, Higginbotham N. "Seeing the baby": pleasures and dilemmas of ultrasound technologies for primiparous Australian women. Med Anthropol Q. 2004 18(1):23-47.
15. Bisits A, Madsen G, Knox M, Gill A, Smith R, Yeo G, Kwek K, Daniel M, Leung TN, Cheung K, Chung T, Jones I, Toohill J, Tudehope D & Giles W. The Randomised Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labour. Am J Obstet Gynecol. 2004 191(3):683-90.
16. Bisits AM, Smith R, Mesiano S, Yeo GSH, Kwek K, MacIntyre DA, Chan E-C. Inflammatory aetiology of human myometrial activation tested using directed graphs. PLoS computational biology [05-PLCB-RA-0040R2] Accepted 4th June 2005.
CHAPTERS17. Smith R, Chan E-C, Mesiano S, Nicholson R, Cheng Y-H, Bowman M, Clifton V, Madsen G, Fitter JT, Giles W, Bisits A. Regulation of Parturition: The Role of CRH. (Chapter 24) Hormones and Women's Health: The Reproductive Years. Vol 1. (2000) Harwood Academic Publishers imprint, part of The Gordon and Breach Publishing Group.Gordon and Breach Science Publishers, 1999.
18. Cole S, Smith R, Bisits A. (2001) Pharmacotherapy for preterm labour. Vol 27 Smith R (Editor). The Endocrinology of Parturition - Basic Science and Clinical Application. In: Frontiers of Hormone Research ed: S. Karger AG. 27:279-307.
19. Smith R, Mesiano S, Nicholson R, Clifton V, Zakar T, Chan E-C, Bisits A, Giles W. The Regulation of Human Parturition. In Birth Distress and Disease. Eds. Michael Power, Jay Schulkin. Publisher: Cambridge University Press, Cambridge UK 2005 pp77-90.
OTHER RELEVANT PUBLICATIONS
Five best publications prior to 1999
2. McLean M, Bisits A, Davies J, Woods R, Lowry P, Smith R. (1995) A placental clock controlling the length of human pregnancy. Nat Med. 1(5):460-3.
3. Lockett M, Bisits A, Giles WB. (1998) Examination of a low-cost pocket Doppler device for fetal assessment.Ultrasound Obstet Gynecol. 11(1):44-7.
4. Giles W, Knox M, Madsen G, Bisits A, Smith R. (1998) The effect of fetal fibronectin usage on admissions to a tertiary maternal fetal medicine unit and cost savings. Am J Obstet Gynecol.178:S121.
5. Bisits A, Madsen G, McLean M, O'Callaghan S, Smith R, Giles W. (1998) Corticotropin-releasing hormone: a biochemical predictor of preterm delivery in a pilot randomized trial of the treatment of preterm labor. Am J Obstet Gynecol.178(4):862-6.
6. Parker J, Bisits A, Proietto AM. (1998) A systematic review of single-dose intramuscular methotrexate for the treatment of ectopic pregnancy. Aust N Z J Obstet Gynaecol. May 38(2):145-50.
CONFERENCE ABSTRACTS
Madsen G, McLean M, Bisits A, O'Callaghan, Giles W, Smith R. Maternal plasma corticotrophin releasing hormone concentrations predict outcome of treatment for preterm labour. 79th Annual Meeting of the Endocrine Society, Minneapolis, USA, June 1997.
Giles W, Bisits A, O'Callaghan S, Gill A. The Doppler assessment in multiple pregnancy study (DAMP) and meta-analysis of Doppler and twins. Perinatal Soc. of Australia and New Zealand 4th Annual Congress Brisbane, March 2000.
Giles W, Knox M, Madsen G, Bisits A, Gill A, Smith R, Jones I, Kwek K, Leung D. The randomised nitric oxide tocolysis trial. Society for Maternal-Fetal Medicine, 21st Annual Meeting, Reno, Nevada, USA. 5th - 10th February, 2001.
McGrath S, McLean M, Smith D, Bisits A, Giles W, Smith R. Maternal plasma corticotropin-releasing hormone trajectories vary depending on the etiology of preterm delivery. 83rd Annual Meeting of the Endocrine Society, Denver CO, USA 20-23rd June, 2001.
Clifton VL, Giles WB, Smith R, Bisits A, Kessell CG, Gibson PG (2001) Inhaled glucocorticoid use for the treatment of asthma during pregnancy does not affect maternal, placental or fetal systemic function. 44th Annual Scientific Meeting of the Endocrine Society of Australia, Gold Coast, Australia, September 9-12, 2001.
Giles W, Knox M, Madsen G, Bisits A, Gill A, Smith R, Jones I, Kwek K, Leung D, Toohill J, Daniel M, Cheung K. The Randomised Nitric Oxide Tocolysis Trial. RANZCOG Annual Scientific Meeting, Melbourne, October 2001.
Giles W, Knox M, Madsen G, Bisits A, Gill A, Smith R, Jones I, Kwek K, Leung D, Toohill J, Daniel M, Cheung K. The Randomised Nitric Oxide Tocolysis trial. 4th Pacific Rim Preterm Labour Meeting, Hong Kong, October 2001.
Giles W, Saison F, Bisits A. Smith R. Fetal subcutaneous fat in pregnancies with and without maternal cigarette smoking. Society for Maternal Fetal Medicine Annual Scientific Meeting. San Francisco, February 2003.
Giles W, Gill A, Bisits A, Madsen G, Knox M, Tudehope D, Rogers Y, Smith R. Fetal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches and IV beta 2 agonist therapy. Society for Maternal Fetal Medicine Annual Scientific Meeting. San Francisco, February 2003.
Chan EC, Bisits A, Yeo GSH, Kwek K, Brown K, Smith R, Mesiano S. (2003) Pattern of gene expression for labour in the human myometrium. Proceedings of the 46th meeting of the Endocrine Society of Australia, Melbourne, September 14-17, 2003.
Zarzycki P, Clifton V Bisits A, Kulhanek K, Smith R. Endocrine discrimination of clinical groups using HPLC driven supramolecular chemistry and PCA statistics. Proceedings of the 46th meeting of the Endocrine Society of Australia, Melbourne, September 14-17, 2003.
Bisits A, Saison F, McGrath S, Smith R, Giles W. Fetal growth is linear in the majority of pregnancies. 8th Annual Congress of the Perinatal Society of Australia and New Zealand Sydney, Australia, 15th-18th March, 2004.
Giles W, Shaw R, Bisits A. Management of the very large obstetric patient outcomes and staff safety issues. 8th Annual Congress of the Perinatal Society of Australia and New Zealand Sydney, Australia, 15th-18th March, 2004.
Swensson A, O'Callaghan S, Bisits A, Walters W. Vascular endothelial cell function is enhanced in late normal human pregnancy. 8th Annual Congress of the Perinatal Society of Australia and New Zealand Sydney, Australia, 15th-18th March, 2004.
Bisits A, Mesiano S, Kwek K, Yeo G, Smith R, Chan E-C. Understanding the initiation of labour with gene expression analysis and path analysis. 8th Annual Congress of the Perinatal Society of Australia and New Zealand Sydney, Australia, 15th-18th March, 2004.
Chan E-C, Bisits A, Mesiano S, Yeo G, Kwek K, Zarzycki P, Brown K, Smith R. Patterns of gene expression in labouring and non-labouring human myometrium. 8th Annual Congress of the Perinatal Society of Australia and New Zealand Sydney, Australia, 15th-18th March, 2004.
Bisits A, Mesiano S, Kwek K, Yeo G, Smith R, Chan E-C. Pathways of gene interactions in the initiation of labour. 51st Annual Scientific Meeting of the Society for Gynecologic Investigation Houston, USA, 24th-27th March, 2004.
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